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目的:通过检测儿童强迫症、抑郁症患者血小板5-羟色胺(5-HT)的浓度,探讨血小板5-HT在儿童强迫症、抑郁症发病中的作用。方法:采用高效液相色谱法检测22例强迫症患儿(包括强迫思维15例,强迫动作7例)和20例抑郁症患儿血小板5-HT的浓度,并与20名正常儿童进行比较。结果:强迫症患儿(173.43±90.67)ng/109和抑郁症患儿(251.62±152.72)ng/109血小板5-HT的浓度低于正常儿童(351.91±170.97)ng/109(P<0.05),强迫症患儿的血小板5-HT的浓度和抑郁症患儿的差异没有显著性(P>0.05)。强迫症患儿中,强迫思维患儿的血小板5-HT的浓度(147.09±44.92)ng/109低于强迫动作患儿(229.88±136.44)ng/109(P<0.05)。结论:儿童强迫症、抑郁症患者血小板5-HT浓度明显下降,并且强迫思维患儿的血小板5-HT浓度与强迫动作患儿的差异有显著性。
Objective: To investigate the role of platelet 5-HT in the development of obsessive-compulsive disorder and depression in children by measuring the concentration of 5-hydroxytryptamine (5-HT) in children with obsessive-compulsive disorder and depression. Methods: The concentrations of platelet 5-HT in 22 obsessive-compulsive children (including 15 cases of obsessive compulsive disorder and 7 cases of obsessive compulsive disorder) and 20 cases of depression were detected by high performance liquid chromatography (HPLC) and compared with 20 normal children. Results: The concentrations of platelet 5-HT in children with obsessive compulsive disorder (173.43 ± 90.67) ng / 109 and depression (251.62 ± 152.72) ng / 109 were lower than those in normal children (351.91 ± 170.97) ng / 109 There was no significant difference in the concentrations of platelet 5-HT and depression among children with obsessive-compulsive disorder (P> 0.05). Compulsive disorder in children with obsessive compulsive thinking in children with platelet 5-HT concentration (147.09 ± 44.92) ng / 109 lower than the forced action in children (229.88 ± 136.44) ng / 109 (P lt; CONCLUSION: The 5-HT concentration of platelets in children with obsessive-compulsive disorder and depression is significantly lower than that of children with obsessive compulsive disorder. The differences of platelet 5-HT concentration and forced action in children with obsessive compulsive disorder are significant.