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目的：研究小檗胶滴眼剂对糖尿病性白内障的防治作用。方法：链脲佐菌素（StreptozotocinSTZ）诱发的大鼠糖尿病性白内障模型，以小檗胺滴眼剂进行防治实验。动物分为预防和治疗两个实验组。结果：（1）预防实验组，小檗胺滴眼剂的预防作用具有剂量依赖性。1％剂量组效果最好，第12周裂隙灯镜检未见核混浊；（2）治疗实验组大鼠晶体混浊度在Ⅳ、Ⅴ期占60％，而糖尿病对照组占90％，结论：小檗胺滴眼剂预防和治疗糖尿病性大鼠白内障具有显著效果。
Objective: To study the preventive and therapeutic effects of barberry gum eye drops on diabetic cataract. Methods: Diabetic cataract model induced by Streptozotocin STZ was treated with berberine eye drops. Animals were divided into prevention and treatment of two experimental groups. Results: (1) The prophylactic experimental group, berberine eye drops preventive effect in a dose-dependent manner. 1% dose group was the best, the first 12 weeks slit lamp microscopy no nuclear opacity; (2) the experimental group rats crystal turbidity in stage Ⅳ, Ⅴ accounted for 60%, while the diabetic control group accounted for 90%, Conclusion: Berberine eye drops have a significant effect in the prevention and treatment of cataract in diabetic rats.