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目的观察脑脊液置换联合鞘内注射在结核性脑膜炎患者中的疗效,并评估其安全性。方法选取2014年5月—2016年5月收治的90例结核性脑膜炎患者,随机分为观察组和对照组,每组45例。对照组给予传统抗结核治疗,观察组患者在传统治疗手段的同时再进行脑脊液置换联合鞘内注射药物,比较两组治疗方案的疗效及安全性。结果对照组总有效率为75.56%,低于观察组的93.33%,说明观察组的有效治愈率有了明显的提升。患者常见的临床症状为发热、颅内高压以及头疼等,结果显示,观察组出现此类症状的时长明显少于对照组,而其他的并发症出现率并无明显差异,由此说明该治疗方案与传统治疗方案相同,均具有较好的安全性。结论脑脊液置换联合鞘内注射在重症脑膜炎患者中的疗效较好,并具有较好的安全性,值得推广借鉴。
Objective To observe the efficacy of cerebrospinal fluid replacement combined with intrathecal injection in patients with tuberculous meningitis and evaluate its safety. Methods Ninety patients with tuberculous meningitis who were admitted from May 2014 to May 2016 were randomly divided into observation group and control group, with 45 cases in each group. The control group was given traditional anti-tuberculosis treatment. Patients in the observation group were treated with conventional replacement of CSF and intrathecal drug. The curative effect and safety of the two groups were compared. Results The total effective rate of the control group was 75.56%, which was lower than 93.33% of the observation group, indicating that the effective cure rate of the observation group has been significantly improved. Patients with clinical symptoms of fever, intracranial hypertension and headache, the results showed that the observation group was significantly shorter duration of such symptoms than the control group, while the incidence of other complications and no significant difference, indicating that the treatment program The same with the traditional treatment programs, all have good safety. Conclusions Cerebrospinal fluid replacement combined with intrathecal injection is effective in patients with severe meningitis and has good safety and is worth promoting.