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目的:探讨霉酚酸酯联合激素对小儿紫癜性肾炎伴新月体者的治疗效果。方法:选取2011年8月-2014年5月间在我院进行治疗的紫癜性肾炎伴新月体患儿80例为研究对象进行回顾性分析,随机分为对照组和研究组,对照组实施常规治疗方案,研究组实施霉酚酸酯联合激素治疗,对比治疗效果。结果:临床分型肾病综合征30例,血尿与蛋白尿36例,孤立性血尿或蛋白尿4例,急性肾炎10例;病理分级72例患者Ⅲ级病变,6例患者Ⅳ级病变,2例患者Ⅴ级病变;研究组治疗完全缓解率90.0%显著高于对照组57.5%,对比差异具有统计学意义(X2=4.382,P<0.05)。结论:霉酚酸酯联合激素治疗小儿紫癜性肾炎伴新月体者患者临床效果好,值得大力推广应用。
Objective: To investigate the effect of mycophenolate mofetil on children with purpura nephritis associated with crescent. Methods: Eighty children with purpura nephritis and crescent who were treated in our hospital from August 2011 to May 2014 were retrospectively analyzed. The patients were randomly divided into control group and study group. The control group Routine treatment programs, the study group implemented mycophenolate mofetil and hormone therapy, the treatment effect. Results: The clinical classification of nephrotic syndrome in 30 cases, hematuria and proteinuria in 36 cases, isolated hematuria or proteinuria in 4 cases, acute nephritis in 10 cases; pathological grade of 72 patients with grade Ⅲ lesions, 6 patients with grade Ⅳ lesions, 2 patients Patients with grade Ⅴ lesions; the study group 90.0% complete remission rate was significantly higher than the control group 57.5%, the difference was statistically significant (X2 = 4.382, P <0.05). Conclusion: Mycophenolate mofetil and hormone treatment of children with purpura nephritis associated with crescent effect is good, it is worth to promote the application.