本实验采用放射免疫法,测量了补骨脂素、8-甲氧基补骨脂素与小鼠S180细胞作用后S180细胞内环核苷酸水平的变化,实验结果表明:8-甲氧基补骨脂素、补骨脂素都能显著提高S180细胞内环核苷酸水平的变化,实验结果表明:8-甲氧基补脂素,补骨脂素都能显著提高S180细胞内cAMP水平,而对其cGMP水平无显著影响,从而极显著地增加了cAMP、cGMP比值,可以抑制细胞的过度增生。 In this experiment, radioimmunoassay was used to measure the changes of cyclic nucleotides in S180 cells after the action of psoralen, 8-methoxypsoralen, and mouse S180 cells. The experimental results showed that: 8-methoxy Psoralen and psoralen could significantly increase the changes of cyclic nucleotides in S180 cells. The experimental results showed that 8-methoxybutanol and psoralen could significantly increase the level of cAMP in S180 cells. , but no significant effect on its cGMP level, which significantly increased the cAMP, cGMP ratio, can inhibit excessive cell proliferation.