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165只家兔经静脉注入人胎盘白蛋白(250 mg/kg两次),可加重由于高胆固醇饲料引起的动脉粥样硬化。58只单纯喂高胆固醇饲料的家兔,动脉硬化发生率为75.9％。加注人胎盘白蛋白者,62只为82.4％,单纯注射异种蛋白者,45只中除个别动物外,没有发生动脉硬化病变。 注射异种蛋白对实验性高胆固醇性动脉粥样硬化的影响在不同条件下有所不同。 喂胆固醇饲料后,发生动脉硬化的动物,其血浆胆固醇水平平均在880 mg ％以上,未发生动脉硬化的动物,则在600 mg ％以下,两者差异有显著性。但血浆胆固醇的高低与动脉硬化面积的大小之间未见平行关系。
Intravenous injection of human placental albumin (250 mg / kg twice) by 165 rabbits increased atherosclerosis due to high cholesterol diets. Fifty-eight rabbits fed pure cholesterol diet had an incidence of atherosclerosis of 75.9%. In addition, only 62.4% of human placenta albumin were injected into the placenta. Only 45% of the 45 infants had no atherosclerotic lesions. The effects of injecting xenogenic proteins on experimental hypercholesterolemic atherosclerosis differ under different conditions. Animals given atherogenic cholesterol after feeding the cholesterol diet had an average plasma cholesterol level of 880 mg% or more, and animals without arteriosclerosis at 600 mg% or less, showing significant differences between the two. However, there is no parallel relationship between the level of plasma cholesterol and the size of atherosclerosis area.