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目的:检测疣状胃炎患者(n=35)外周血T淋巴细胞亚群CD_3+、CD_4+、CD_8+,并与107例慢性浅表性胃炎中的幽门螺杆菌(Hp)感染的患者(n=16)比较。方法:所有患者均通过胃粘膜活检快速尿素酶试验和~(14)C-尿素呼气试验以确定是否有Hp感染,用流式细胞术方法检测疣状胃炎和Hp感染的浅表性胃炎患者外周血T淋巴细胞亚群CD_3+、CD_4+、CD_8+。结果:疣状胃炎Hp感染率明显高于慢性浅表性胃炎者(P<0.01);与Hp感染的浅表性胃炎比较,疣状胃炎CD_3+、CD_8+降低以及CD_4+/CD_8+比值增加(P<0.01,P<0.05)。疣状胃炎中Hp阳性组与Hp阴性组比较CD_8也明显降低(P<0.05)。结论:疣状胃炎发病可能有免疫因素参与。
Objective: To detect CD_3 +, CD_4 + and CD_8 + of T lymphocyte subsets in patients with verrucous gastritis (n = 35) and to investigate the relationship between Helicobacter pylori (Hp) infection and 107 patients with chronic superficial gastritis (n = 16) Compare Methods: All patients underwent gastric mucosal biopsy with rapid urease test and ~ (14) C-urea breath test to determine whether there was Hp infection. Flow cytometry was used to detect verrucous gastritis and Hp-infected patients with superficial gastritis Peripheral blood T lymphocyte subsets CD_3 +, CD_4 +, CD_8 +. Results: The prevalence of Hp infection in verrucous gastritis was significantly higher than that in chronic superficial gastritis (P <0.01). Compared with superficial gastritis with Hp infection, the ratio of CD_3 +, CD_8 + and CD_4 + / CD_8 + increased , P <0.05). In verrucous gastritis, Hp positive group and Hp negative group CD_8 also significantly lower (P <0.05). Conclusion: There may be immune factors involved in the pathogenesis of verrucous gastritis.