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目的探究大学生接种不同剂量乙肝疫苗的免疫效果。方法择取位于广东省佛山市南海区狮山镇社区某高等院校2012-2014年进行乙肝病毒检测后显示为乙肝表面抗原阴性者3 000人次纳入本次实验研究,依照信封随机分组方案分为每组均占据1 500人次的常规组与实验组,其中常规组给予小剂量乙肝疫苗接种程序,实验组给予大剂量乙肝疫苗接种程序,分析乙肝疫苗的免疫效果。结果实验组的接种阳性率明显高于常规组,其中实验组接种1个月、2个月、12个月的阳性率分别为93.47%、91.13%和88.87%。结论给予大剂量乙肝疫苗接种的免疫效果十分显著,值得推荐采纳。
Objective To explore the immune effect of university students vaccinated with different doses of hepatitis B vaccine. METHODS: A total of 3 000 persons, who were negative for hepatitis B surface antigen (HBsAg) after hepatitis B virus detection in 2012-2014 in Shishan Town, Nanhai District, Foshan City, Guangdong Province, were included in this study. According to the randomized grouping plan, Each group occupies 1 500 routine and experimental groups, of which routine group given small doses of hepatitis B vaccination program, experimental group given high-dose hepatitis B vaccination program to analyze the immune effect of hepatitis B vaccine. Results The positive rate of inoculation in experimental group was significantly higher than that in conventional group. The positive rates of experimental group at 1 month, 2 months and 12 months were 93.47%, 91.13% and 88.87% respectively. Conclusion The immunization effect of high-dose hepatitis B vaccination is very significant, it is recommended to adopt.