论文部分内容阅读
[目的]探讨胃脘痛胃黏膜异型增生患者中医微观辨证分型与CdX2基因蛋白表达的意义及与临床随访结果的关系。[方法]应用中医脏腑辨证理论与ABC免疫组化方法对120例胃脘痛胃黏膜异型增生患者进行胃镜下微观辨证分型与CdX2基因蛋白表达的免疫组化分析,同时进行临床随访研究。[结果]胃络瘀滞型与胃络灼伤型患者胃黏膜CdX2基因蛋白表达阳性率(37.5％、66.7％)较胃寒型与胃热型(6.7％、12.5％)明显增高(P<0.01),其中具有完整随访结果者63例,随访时间6-72个月(平均24个月),其癌变者中胃络瘀滞型(76.7％)明显高于未癌变者(27.3％)(P<0.01)。[结论]中医微观辨证分型与CdX2基因蛋白表达有关,对辨别胃黏膜异型增生的癌变性质具有重要意义,胃络瘀滞型胃黏膜异型增生与癌变关系密切,在辨证施治中应给予重视。
[Objective] To investigate the significance of TCM syndrome differentiation and expression of CdX2 protein in gastric mucosal dysplasia patients with gastric mucosal pain and its relationship with clinical follow-up results. [Method] Applying TCM Syndrome Differentiation Theory and ABC immunohistochemical method to 120 cases of gastric dyspepsia patients with gastric mucosal dysplasia, we carried out the immunohistochemical analysis of microscopic differential syndrome type and CdX2 gene expression in gastroscope. At the same time, we conducted clinical follow-up study. [Results] The positive rates of CdX2 gene protein expression in stomach mucosa with stomach stasis type and gastric burns type were significantly higher than those with stomach type and stomach type (6.7%, 12.5%, P <0.01) ), Of which 63 had complete follow-up results. The follow-up time ranged from 6 to 72 months (mean, 24 months). The gastric stasis type (76.7%) in cancerous patients was significantly higher than that in non-cancerous patients <0.01). [Conclusion] The microscopic differentiation of traditional Chinese medicine is related to the expression of CdX2 gene protein, which is of great significance in differentiating the carcinomatous nature of gastric dysplasia. The gastric dysplasia associated with gastric stasis is closely related to carcinogenesis, and should be given more attention in syndrome differentiation .