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目的探讨冠心病合并亚临床甲状腺功能减退症患者的甲状腺功能与超敏C-反应蛋白(hs-CRP)、颈动脉中值厚度(IMT)的相关性。方法选择2014年9月-2015年6月在本院心内科住院或门诊就诊已确诊的冠心病患者及合并未经治疗的亚临床甲状腺功能减退症患者108例,其中冠心病合并亚临床甲状腺功能减退症患者58例,单纯冠心病患者50例。分别测定TSH、FT3、FT4、FIB、TG、TC及IMT和hs-CRP。结果冠心病合并亚临床甲状腺功能减退症组较冠心病组TG、TC、hs-CRP、IMT升高,差异均有统计学意义(P<0.05)。TSH与TC、TG、hs-CRP、IMT呈正相关(r值分别为0.276、0.309、0.397、0.391,P<0.05),而与LDL-C及HDL-C无明显相关性(P>0.05)。结论通过测定超敏-C反应蛋白、颈动脉中值厚度水平及促甲状腺激素可能对冠心病患者发生亚临床甲状腺功能减退症的诊断及治疗起到辅助作用。
Objective To investigate the correlation between thyroid function and hs-CRP and carotid artery mean thickness (IMT) in patients with coronary heart disease and subclinical hypothyroidism. Methods From September 2014 to June 2015, 108 patients with confirmed CHD and hospitalized hypothyroidism with subclinical hypothyroidism were enrolled in our department. Among them, 108 were CHD with subclinical thyroid function 58 patients with hypothyroidism, 50 patients with simple coronary heart disease. TSH, FT3, FT4, FIB, TG, TC, IMT and hs-CRP were measured respectively. Results The levels of TG, TC, hs-CRP and IMT in CHD patients with subclinical hypothyroidism were significantly higher than those in CHD patients (P <0.05). TSH was positively correlated with TC, TG, hs-CRP and IMT (r = 0.276,0.309,0.397,0.391, P <0.05), but no significant correlation with LDL-C and HDL-C (P> 0.05). Conclusion The determination of high-sensitivity C-reactive protein, carotid artery median thickness and thyrotropin may play an auxiliary role in the diagnosis and treatment of subclinical hypothyroidism in patients with coronary heart disease.