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目的 :评价国产双酒石酸长春瑞滨注射液 (以下称民诺宾 )对中晚期非小细胞肺癌及乳腺癌的疗效和不良反应 ,并与进口同类产品进行比较。方法 :全组非小细胞肺癌 (NSCLC)和乳腺癌 (BC) 14 9例 ,随机进入治疗组(国产民诺宾 )及对照组 (进口NVB) ,分别给予NP、NIP、NE(或NA)方案及单药化疗 ,两组所用药物及剂量、方法完全一致。结果 :治疗组与对照组治疗非小细胞肺癌有效率分别为 2 6 .7%和 2 8.6 % (P >0 .0 5 ) ,乳腺癌分别为 4 2 .9%和4 6 .7% (P >0 .0 5 ) ,毒性反应主要是骨髓抑制和消化道反应 ,治疗组与对照组WBC下降发生率分别为 87.5 %和90 % ,血小板下降分别为 4 0 %和 38% ,消化道反应分别为 82 .5 %和 78% ,组间无显著性差异。结论 :国产双酒石酸长春瑞滨注射液 (民诺宾 )疗效确切 ,有效率和毒性反应均与国外同类产品相似
OBJECTIVE: To evaluate the curative effect and side effects of domestic vinorelbine tartrate injection (hereinafter referred to as Minobin) on advanced non-small cell lung cancer and breast cancer and to compare with imported similar products. METHODS: A total of 149 NSCLC and BC cases were randomly divided into treatment group (nominobin) and control group (nVB). NP, NIP, NE (or NA) Program and single-drug chemotherapy, the two groups of drugs and dosage, the method is exactly the same. Results: The effective rates of treatment for non-small cell lung cancer and control group were 26.7% and 22.6% (P> 0.05) respectively, while those in breast cancer were 42.9% and 46.7% P> 0.05). The main toxic reactions were myelosuppression and gastrointestinal reaction. The incidences of WBC in treatment group and control group were 87.5% and 90% respectively, and the platelet counts were 40% and 38% respectively. The gastrointestinal reactions Respectively, 82.5% and 78%, no significant difference between the groups. Conclusion: Domestic vinorelbine tartrate injection (Minobu Bin) efficacy, efficacy and toxicity are similar to similar foreign products