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目的研究β-半乳糖凝集素3(Gal-3)和生物钟基因PER2在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。方法采用免疫组化法检测Ga1-3蛋白和生物钟基因PER2在90例NSCLC组织和20例正常肺组织中的表达。结果在NSCLC组织中和正常组织中Ga1-3蛋白的阳性表达率分别为56.7%、25%(P<0.05),PER2的阳性表达率分别为58.9%、85%(P<0.05)。Gal-3的表达与NSCLC分化程度、淋巴结转移情况和TNM分期有关(P<0.05)。结论与正常组织相比较,在非小细胞肺癌中,Gal-3呈高表达,PER2呈低表达。推测Gal-3、PER2在NSCLC的发生、发展中可能起到重要作用。
Objective To investigate the expression and clinical significance of β-galectin-3 (GLA-3) and the circadian clock gene PER2 in non-small cell lung cancer (NSCLC). Methods The expression of Ga1-3 protein and PER2 gene in 90 NSCLC tissues and 20 normal lung tissues were detected by immunohistochemistry. Results The positive expression rates of Ga1-3 protein in NSCLC tissues and normal tissues were 56.7% and 25%, respectively (P <0.05). The positive rates of PER2 were 58.9% and 85% respectively (P <0.05). The expression of Gal-3 was correlated with the degree of NSCLC differentiation, lymph node metastasis and TNM staging (P <0.05). Conclusion Compared with normal tissue, Gal-3 is highly expressed and PER2 is low expressed in non-small cell lung cancer. Speculated that Gal-3, PER2 may play an important role in the occurrence and development of NSCLC.