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目的分析中药注射剂的不良反应。方法收集103例中药注射剂的不良反应报告资料,总结其发生原因和临床表现。结果 103例均为静脉滴注给药的患者。其中,应用参麦注射液34例(33.01%),血必净注射液14例(13.59%)。不良反应出现在滴注30min内者68例(66.02%)。可能原因:溶媒选择不当者34例(33.01%),给药途径不当者21例(20.39%),输液速度过快者13例(12.62%),个体差异14例(13.59%),原因不确定者21例(20.39%)。临床表现:皮肤及软组织的皮疹、荨麻疹和皮肤瘙痒者68例(66.03%);寒战、发热、紫绀、胸闷、胸痛、心悸、恶心呕吐、腹痛、便秘、头晕、头痛、呃逆和大汗等全身性反应者21例(20.39%);腰痛、肌肉痛、静脉炎、喉痛、咳嗽、注射部位静脉疼痛等局部反应者14例(13.59%)。所有病例经相应处理后症状消失。结论随着中药注射剂广泛的临床应用,需要重视其不良反应的发生,应当针对其不良反应的发生原因,采取有效的防治措施,安全应用中药注射剂。
Objective To analyze the adverse reactions of traditional Chinese medicine injection. Methods A total of 103 cases of traditional Chinese medicine injection of adverse reaction data were collected to summarize the causes and clinical manifestations. Results 103 cases were intravenously administered patients. Among them, 34 cases (33.01%) of Shenmai injection and 14 cases (13.59%) of Xuebijing injection were applied. Adverse reactions occurred in 30 minutes infusion of 68 patients (66.02%). Probable causes: 34 cases (33.01%) were chosen improperly, 21 cases (20.39%) were improperly administered, 13 cases (12.62%) had excessive infusion rate, and 14 cases (13.59% 21 cases (20.39%). Clinical manifestations: skin and soft tissue rash, urticaria and skin itching in 68 cases (66.03%); chills, fever, cyanosis, chest tightness, chest pain, palpitations, nausea and vomiting, abdominal pain, constipation, dizziness, headache, hiccups and sweating There were 21 cases (20.39%) of systemic reactions and 14 cases (13.59%) of local reactions such as low back pain, muscle pain, phlebitis, sore throat, cough and venous pain at injection site. All cases disappeared after the corresponding treatment. Conclusion With the extensive clinical application of traditional Chinese medicine injections, it is necessary to pay attention to the occurrence of adverse reactions. In order to prevent the occurrence of adverse reactions, effective prevention and cure measures should be taken to safely apply traditional Chinese medicine injections.