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为探讨慢性肾衰患者不同透析膜透析时氧自由基的氧化损伤，对维持性血透病人使用铜仿膜、聚砜膜及血仿膜透析，分别检测透析前、后血浆和红细胞脂质过氧化物（ Ｌ Ｐ Ｏ） 、超氧化物歧化酶（ Ｓ Ｏ Ｄ） 及全血谷胱甘肽过氧化物酶（ Ｇ Ｐ Ｘ） 活性，并与健康组对照。结果示铜仿膜透析后红细胞 Ｌ Ｐ Ｏ 显著增加， Ｓ Ｏ Ｄ 活性显著降低，聚砜膜和血仿膜则变化不明显。揭示使用聚砜膜或血仿膜行长期血透可防治患者因氧自由基增加产生的并发症。
To investigate oxidative damage of oxygen free radicals during dialysis of chronic dialysis patients with chronic renal failure, broncho-membranous membrane, polysulfone membrane and hemephemodialysis were used in patients with maintenance hemodialysis to detect plasma and erythrocyte lipids before and after dialysis (L P O), superoxide dismutase (SOD) and whole blood glutathione peroxidase (G P X) activity, and compared with the healthy group. The results showed that after copper-coated dialysis, the red blood cells L P O significantly increased, S O D activity decreased significantly, polysulfone membrane and heme membrane did not change significantly. Reveal the use of polysulfone membrane or hematum membrane long-term hemodialysis can prevent patients due to increased oxygen free radicals generated complications.