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目的探讨正常妊娠孕妇在孕早、中、晚期外周血中肥胖抑制素(Obestatin)和多功能脑肠肽(Ghrelin)的变化,以及Ghrelin/Obestatin比值与血脂及胰岛素抵抗之间的关系。方法选取2011年1月至2013年12月于武警后勤学院附属医院门诊产检的正常妊娠孕妇30例作为观察对象,分别于孕早期(8~12周)、孕中期(20~24周)、孕晚期(32~36周)抽取外周血检测相关指标。结果孕妇外周血中Ghrelin于孕中期升高达高蜂,孕晚期回降至孕早期水平(P值分别为0.002、0.012、0.072);孕妇外周血中Obestatin浓度随孕期增加而增高,孕晚期升高达高蜂(P值分别为0.021、0.032、0.026);孕中期及孕晚期Ghrelin/Obestatin比值与总脂固醇(TCH)和甘油三酯(TC)水平呈正相关(r值分别为0.852、0.718、0.775、0.814,均P<0.05),与胰岛素抵抗指数(HOMA-IR)呈负相关(r值分别为-0.847、-0.862,均P<0.05)。结论正常妊娠孕妇,外周血Obestatin和Ghrelin水平于不同孕期出现明显变化。Obestatin和Ghrelin共同调节孕妇的脂代谢和糖代谢。
Objective To investigate the changes of Obestatin and Ghrelin in normal pregnant women in the early, middle and late stages of pregnancy and the relationship between Ghrelin / Obestatin ratio and serum lipids and insulin resistance. Methods Thirty healthy pregnant women who were diagnosed at the outpatient department of Affiliated Hospital of Armed Police Forces Hospital from January 2011 to December 2013 were selected as observational objects. The pregnant women in the first trimester of pregnancy (8-12 weeks), second trimester (20-24 weeks) Late (32 to 36 weeks) to extract peripheral blood test-related indicators. Results Ghrelin in peripheral blood of pregnant women increased up to high in the second trimester, and then dropped back to the first trimester in the third trimester (P = 0.002,0.012,0.072, respectively). The concentration of Obestatin in pregnant women increased with the increase of pregnancy, (P = 0.021, 0.032, 0.026, respectively). The ratio of Ghrelin / Obestatin in the second trimester and third trimester was positively correlated with total cholesterol and triglyceride (r = 0.852, 0.718, 0.775,0.814, all P <0.05), but negatively correlated with HOMA-IR (r = -0.847, -0.862, all P <0.05). Conclusion The levels of Obestatin and Ghrelin in normal pregnant women and their peripheral blood have significant changes at different gestations. Obestatin and Ghrelin regulate lipid metabolism and glucose metabolism in pregnant women.