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目的:分析2型糖尿病患者采用4次胰岛素皮下注射、门冬胰岛素30注射液皮下注射、胰岛素泵持续皮下输注等3种胰岛素强化降糖方案的血糖达标时间、胰岛素的用量、低血糖情况,比较其安全性及有效性、适用人群。方法:选取2011年3月-2014年12月本院收治的75例2型糖尿病患者作为研究对象,收集患者的临床资料,对2型糖尿病的诊治情况进行回顾性分析,按照住院时的降糖方案分为4次胰岛素皮下注射组、门冬胰岛素30注射液皮下注射组、胰岛素泵持续皮下输注组,比较观察各组末梢血糖控制达标时间、胰岛素总量、低血糖情况。结果:3组患者治疗后空腹及餐后血糖与治疗前比较,差异具有统计学意义(P<0.05);胰岛素泵持续皮下输注组血糖控制达标时间少于4次胰岛素皮下注射组、门冬胰岛素30注射液皮下注射组(P<0.05);胰岛素泵持续皮下输注组胰岛素总量少于4次胰岛素皮下注射组、门冬胰岛素30注射液皮下注射组(P<0.05);低血糖发生率3组无明显差别。结论:4次胰岛素皮下注射、门冬胰岛素30注射液皮下注射、胰岛素泵持续皮下输注等胰岛素强化治疗方案均能使空腹及餐后血糖改善,胰岛素泵持续皮下输注血糖下降更平稳、血糖达标时间较短,但治疗费用相对较高,门冬胰岛素30注射液皮下注射由于注射次数少使患者依从性较高,4次胰岛素皮下注射可能给患者生活带来不便使依从性下降。门冬胰岛素30注射液皮下注射更适合老年糖尿病需胰岛素强化治疗者。
OBJECTIVE: To analyze the duration of glycemic control, insulin dosage and hypoglycemia in patients with type 2 diabetes treated with subcutaneous insulin infusion 4 times, subcutaneous injection of insulin aspart 30 injection and sustained subcutaneous infusion of insulin pump, Compare its safety and effectiveness, apply to the crowd. Methods: From March 2011 to December 2014, 75 patients with type 2 diabetes mellitus admitted to our hospital were selected as the research object. The clinical data of patients were collected. The diagnosis and treatment of type 2 diabetes were retrospectively analyzed. According to the hypoglycemic The program was divided into four subcutaneous insulin injection groups, insulin aspart 30 injection subcutaneously, insulin pump subcutaneous infusion group continued to observe the control group of the final blood glucose control time, the total amount of insulin, hypoglycemia. Results: The fasting blood glucose and postprandial blood glucose in three groups after treatment were significantly different from those before treatment (P <0.05). The insulin control subcutaneous injection group had less blood glucose control than the 4 subcutaneous insulin injection groups, (P <0.05). Insulin pump sustained subcutaneous infusion group insulin subcutaneous injection group less than 4 times insulin subcutaneous injection group, insulin aspart 30 injection subcutaneous injection group (P <0.05); hypoglycemia Rate 3 groups no significant difference. Conclusion: The fasting and postprandial blood glucose can be improved by subcutaneous injection of insulin 4 times, subcutaneous injection of insulin aspart 30 injection and sustained subcutaneous infusion of insulin pump. The fasting and postprandial blood glucose can be improved, Shorter target time, but the relatively high cost of treatment, insulin aspart 30 injection due to the low number of injections so that patients with higher compliance, 4 subcutaneous insulin injection may cause inconvenience in patients with decreased compliance. Insulin aspart 30 injection subcutaneous injection is more suitable for elderly patients with diabetes requiring intensive treatment of insulin.