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目的:观察不同剂量前列地尔对心绞痛患者C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的影响。方法:选择武装警察部队海警总队医院2017年8月至2018年4月收治的心绞痛患者120例为观察对象，采用随机数字表法分为对照组60例、观察组60例。两组患者均接受常规抗心绞痛治疗，对照组患者使用10 μg前列地尔治疗，观察组患者给予20 μg前列地尔治疗，两组疗程均为2周。比较两组患者治疗前后CRP、TNF-α、IL-6变化及血液流变学指标变化。结果:治疗前，两组CRP、TNF-α、IL-6差异均无统计学意义(均n P>0.05)。治疗后，观察组CRP、TNF-α、IL-6分别为(4.63±0.62)mg/L、(0.46±0.08)μg/L、(46.59±4.72)ng/L，均明显低于对照组的(6.18±0.74)mg/L、(1.19±0.28)μg/L、(58.62±5.07)ng/L(n t＝12.437、19.418、13.452，均n P<0.05)；观察组高切、低切黏度及血浆黏度、血小板聚集率分别为(4.27±0.46)mPa/s、(8.07±0.18)mPa/s、(1.03±0.25)mPa/s、(37.42±1.05)%，均低于对照组的(5.14±0.588)mPa/s、(10.43±0.42)mPa/s、(2.01±0.46)mPa/s、(40.19±1.86)%(n t＝9.103、40.006、14.499、10.046，均n P0.05). After treatment, the CRP, TNF-α and IL-6 levels in the observation group were (4.63±0.62)mg/L, (0.46±0.08)μg/L, (46.59±4.72)ng/L, respectively, which were significantly lower than those in the control group [(6.18±0.74)mg/L, (1.19±0.28)μg/L, (58.62±5.07)ng/L](n t=12.437, 19.418, 13.452, all n P<0.05). The high shear viscosity, low shear viscosity, plasma viscosity and platelet aggregation rates in the observation group were (4.27±0.46)mPa/s, (8.07±0.18)mPa/s, (1.03±0.25)mPa/s, (37.42±1.05)%, respectively, which were lower than those in the control group [(5.14±0.588)mPa/s, (10.43±0.42)mPa/s, (2.01±0.46)mPa/s, (40.19±1.86)%] (n t=9.103, 40.006, 14.499, 10.046, all n P<0.05).n Conclusion:The conventional dose of alprostadil (20 μg) is effective in the treatment of angina pectoris.It can improve CRP, TNF-α, IL-6 and hemorheological parameters of patients.