论文部分内容阅读
人干扰素(IFN)是由人体细胞分泌的一类蛋白质,具有抗病毒抗肿瘤以及免疫调节作用。近十多年来的临床研究资料证明,干扰素是一种有希望的新药。1935年以前已有临床工作者注意到一个脏器被一种病毒感染后,能阻止另一种病毒在同一脏器中生长,这就是所谓病毒间的干扰现象。1957年Isaacs和Lindenmann在研究流感病毒的干扰现象时,发现了干扰素。这一发现很快引起了广泛的注意。它可以控制流感、感冒及许多其他病毒性疾病。但因当时制备IFN有困难,直到1962年才有首次用于人的报告。在被试者皮下注射IFN 24小时后,于同一部位接种痘苗结果可阻止痘苗反应发展,证明IFN有抗病毒效力。此后,由于IFN的来源困难,故研究工作没有得到预期的进展。近来因证实了IFN有抗癌作用而再度引起人们
Human interferon (IFN) is a type of protein secreted by human cells and has antiviral, antitumor, and immunomodulatory effects. The clinical research data of more than a decade have proven that interferon is a promising new drug. Before 1935, when clinicians noticed that an organ was infected by a virus, it prevented another virus from growing in the same organ. This is known as inter-viral interference. In 1957, Isaacs and Lindenmann discovered interferon when studying the interference of influenza virus. This discovery quickly attracted widespread attention. It can control the flu, colds and many other viral diseases. However, due to difficulties in the preparation of IFN at that time, it was not until 1962 that the report was first used for humans. After the subjects injected IFN subcutaneously for 24 hours, the results of vaccination at the same site prevented the development of vaccinia response, demonstrating that IFN has antiviral efficacy. Since then, due to the difficulty in the origin of IFN, the research work has not achieved the expected progress. Recently it has caused people to reinvigorate because of the proven anti-cancer effect of IFN.