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目的探讨颅内生殖细胞瘤治疗后复发的原因。方法回顾性分析79例颅内生殖细胞瘤患者的临床资料。结果治疗后3个月评价近期疗效,各种治疗方法均获得100%有效率。随访2a,11例(13.9%)复发和转移,转移或复发中位时间12.6个月;复发者松果体区病变(63.6%)高于病情稳定者(42.7%),症状与发病部位有关;稳定组72.1%患者采用放、化疗联合治疗,复发组72.7%患者以单一治疗为主,3例γ-刀治疗患者复发后再行放、化疗联合治疗,均获得理想效果。结论早期诊断和规范手术治疗并合理联合放、化疗可有效控制颅内生殖细胞瘤,减少复发及转移。
Objective To investigate the causes of intracranial germinoma recurrence after treatment. Methods The clinical data of 79 patients with intracranial germinoma were retrospectively analyzed. Results Three months after the treatment, the short-term efficacy was evaluated, and all the treatments were 100% effective. Follow-up 2a, 11 patients (13.9%) had a median recurrence and metastasis of 12.6 months. The recurrence rate of the pineal region (63.6%) was higher than that of the stable condition (42.7%). The symptoms were related to the site of disease. In the stable group, 72.1% of the patients were treated with radiotherapy and chemotherapy, 72.7% of the patients in the recurrence group were treated with single therapy, and 3 patients with γ-knife relapsed after radiotherapy and radiotherapy combined with chemotherapy were the ideal results. Conclusion Early diagnosis and standard surgical treatment and reasonable combination radiotherapy and chemotherapy can effectively control intracranial germinoma and reduce the recurrence and metastasis.