缺氧诱导因子 - 1(HIF- 1)首先由 Semenza1992年在缺氧的细胞核中首先发现的 ,可与人 EPO 3’增强子序列结合并促进其转录的一种核转录因子。它是在缺氧等条件下广泛存在于哺乳动物和人体内的一种蛋白质 ,可以与下游的靶基因结合 ,并促进其转录 ,使机体产生一系列耐受缺氧的反应 Hypoxia-inducible factor-1 (HIF-1) was first identified by Semenza as a nuclear transcription factor found in 1982 cortical DNA-based assays and binds to human EPO 3 ’enhancer sequence and promotes its transcription. It is hypoxia and other conditions widely exist in mammals and humans in a protein that can target the downstream genes and promote its transcription, the body produces a series of hypoxia-tolerant response