论文部分内容阅读
利福昔明为利福霉素的衍生物,抗菌谱与利福平相似,因在胃肠道中难吸收,主要用于肠道感染和肠道疾病,已证明对于由大肠埃希菌引起的旅游者腹泻本品的疗效与环丙沙星相当,但对由空肠弯曲杆菌引起的感染无效,利福昔明也已用于其他胃肠道病症的治疗,如肝性脑病、肠内胀气及与气体相关的症状、憩室病、肠内细菌过度增殖、慢性肠炎、溃疡性结肠炎和活动期节段性回肠炎等。一些研究证明利福昔明用于治疗旅游者腹泻以及其他胃肠道疾病的疗效、药动学、适应证、不良反应、禁忌证、警告和剂量。
Rifaximin is a derivative of rifamycin, antimicrobial spectrum similar to rifampicin, due to its difficult to absorb in the gastrointestinal tract, mainly for intestinal infections and intestinal diseases, has been proved by the Escherichia coli caused This product has the same efficacy as ciprofloxacin but has no effect on infections caused by Campylobacter jejuni. Rifaximin has also been used in the treatment of other gastrointestinal disorders such as hepatic encephalopathy, intestinal flatulence and Gas-related symptoms, diverticular disease, intestinal bacterial overgrowth, chronic enteritis, ulcerative colitis and active Crohn’s disease and so on. Several studies have demonstrated the efficacy, pharmacokinetics, indications, side effects, contraindications, warnings and doses of rifaximin for the treatment of diarrhea in travelers and other gastrointestinal disorders.