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目的观察缬沙坦与小剂量氢氯噻嗪联合治疗高血压的临床疗效及不良反应。方法将116例高血压病患者随机分为两组各58例,治疗组:联合应用缬沙坦及小剂量氢氯噻嗪控制血压治疗;对照组:单用缬沙坦控制血压治疗。疗程均为4周,比较2组患者的降压疗效及不良反应。结果治疗组控制血压的总有效率为91.38%,对照组控制血压的总有效率为81.03%,两组患者控制血压总有效率比较差异有统计学意义(P<0.05);2组患者药物不良反应发生率分别为10.34%、8.62%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论缬沙坦和小剂量氢氯噻嗪合用降压疗效好,不良反应无明显增加,值得临床推广应用。
Objective To observe the clinical efficacy and adverse reactions of valsartan combined with low-dose hydrochlorothiazide in the treatment of hypertension. Methods A total of 116 patients with essential hypertension were randomly divided into two groups of 58 patients. The treatment group was treated with valsartan and low-dose hydrochlorothiazide to control blood pressure. The control group was treated with valsartan alone. The course of treatment was 4 weeks. The antihypertensive efficacy and adverse reactions in 2 groups were compared. Results The total effective rate of blood pressure control was 91.38% in the treatment group and 81.03% in the control group. The total effective rate of blood pressure control in the two groups was statistically significant (P <0.05). The adverse drug reactions in the two groups The incidence of reaction was 10.34% and 8.62%, respectively. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Valsartan and low-dose hydrochlorothiazide combined antihypertensive effect is good, no significant increase in adverse reactions, worthy of clinical application.