恶性肿瘤的成因与增殖失控,凋亡受阻有关.促进凋亡治疗开创了肿瘤治疗新模式.我国学者最近报道砷剂(主要成分三氧化二砷,As_2O_3)治疗急性早幼粒细胞白血病(APL),无论对初治还复发及难治病例均有明显疗效,并证实As_2O_3可诱导APL细胞凋亡,为促凋亡治疗提供了成功的范例.为了解As_2O_3对乳癌的影响及作用机制,本文观察了三氧化二砷注射剂诱导乳癌细胞凋亡的作用.采用MTT法检测药物半数抑制剂量(IC50),三氧化二砷注射剂处理人乳癌细胞 The causes of malignant tumors are related to the uncontrolled proliferation and the inhibition of apoptosis. The promotion of apoptosis treatment has created a new model for cancer treatment. Chinese scholars recently reported that arsenic (mainly composed of arsenic trioxide, As2O3) is used to treat acute promyelocytic leukemia (APL). The initial treatment of relapsed and refractory cases have obvious curative effect, and confirmed that As2O3 can induce apoptosis of APL cells, providing a successful example of pro-apoptotic therapy. In order to understand the effect of As2O3 on breast cancer and its mechanism of action, this article observed the arsenic trioxide injection Induction of apoptosis in breast cancer cells. MTT assay was used to determine the IC50, and arsenic trioxide injection was used to treat human breast cancer cells.