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目的 :探讨等位基因HLA DQA1及DQB1在国人Graves′病 (graves′disease ,GD)发病中的作用。方法 :选择汉族GD患者 10 3例及正常人 10 0例。采用PCR SSP方法 ,检验HLA DQA1 0 5 0 1、DQB1 0 2 0 1及DQB1 0 3 0 3的出现频率。结果 :HLA DQA1 0 5 0 1及DQB1 0 2 0 1GD组均低于对照组 (分别P =0 0 0 2 ,RR =0 .3 8及P =0 .0 0 1,RR =0 .2 7) ,DQB1 0 3 0 3GD组与对照组之间无差异 (P =0 .189RR =0 .64)。研究提示DQA1 0 5 0 1、DQB1 0 2 0 1为中国汉族人群GD的保护因素。以上 3种基因在不同性别GD患者之间均未见差异。结论 :HLA DQ与国人GD的发病有关。GD患者DQA1 0 5 0 1及DQB1 0 2 0 1出现频率减少。
Objective: To investigate the role of alleles HLA DQA1 and DQB1 in the pathogenesis of Graves’ disease (GD) in Chinese. Methods: A total of 103 Han patients with GD and 100 normal subjects were selected. The PCR SSP method was used to test the frequency of appearance of HLA DQA10501, DQB1 0 2 0 1 and DQB1 0 3 0 3. Results: The HLA DQA1 0501 and DQB1 0 2 0 1GD groups were significantly lower than those of the control group (P = 0.002, RR = 0.38, P = .0 0, RR = 0.27 ), There was no difference between DQB1 0 3 0 3GD group and control group (P = 0.189RR = 0.64). Research suggests that DQA1 0501 and DQB1 0201 are protective factors for GD in Chinese Han population. There was no difference between the above three genes in GD patients of different genders. Conclusion: HLA DQ is associated with the incidence of GD in Chinese. GD patients DQA1 0 5 0 1 and DQB1 0 2 0 1 frequency of decrease.