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t(9;22)(q34q11)在CML患者的阳性率达90％以上,成人ALL为20％～40％,而儿童ALL为2.3％～5％。分子生物学证实这种移位是由于9及22号染色体上正常的ABL和BCR基因分裂编码了一种具有翻译能力的融合蛋白的嵌合体BCR/ABL基因。本文的前瞻性研究证实了具有此种基因的初诊ALL患儿的发生
The positive rate of t (9; 22) (q34q11) was over 90% in CML patients, 20% -40% in adult ALL, and 2.3% -5% in children with ALL. Molecular biology has confirmed that this shift is due to the cleavage of the normal ABL and BCR genes on chromosomes 9 and 22 by a chimeric BCR / ABL gene encoding a translational fusion protein. Our prospective study confirmed the occurrence of newly diagnosed ALL children with this gene