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目的:优选以牛血清白蛋白为载体的氟尿嘧啶磁亚微球的制备工艺,并考察其体外释药。方法:以载药量、包封率、平均粒径及形态为考察指标,采用均匀设计法及单因素试验设计法筛选优化磁亚微球的最佳制备工艺,并进一步采用体外动态释药法评价其释药特征。结果:以优化工艺制备的磁亚微球形态良好,平均粒径为(330±21)nm,载药量为(9.5±1.2)%,包封率为(68.3±2.0)%,磁响应性能良好。磁亚微球体外释药规律符合Higuchi方程,具有一定的缓释作用。结论:均匀设计法结合单因素试验设计优化筛选氟尿嘧啶磁亚微球最佳制备工艺科学合理,为制备氟尿嘧啶磁亚微球提供了理论依据。
OBJECTIVE: To optimize the preparation of fluorouracil magnetic submicrospheres with bovine serum albumin (BSA) as carrier and study its in vitro drug release. Methods: Taking drug loading, entrapment efficiency, average particle size and morphology as index, the optimal preparation process of magnetic submicrosphere was optimized by uniform design and single factor experiment design method, and the dynamic in vitro release method Evaluation of its release characteristics. Results: The morphology of the magnetic submicrospheres prepared by the optimized process was good. The average diameter was (330 ± 21) nm, the drug loading was (9.5 ± 1.2)% and the encapsulation efficiency was (68.3 ± 2.0)%. good. Magnetic submicrospheres in vitro release law in line with Higuchi equation, with a certain degree of sustained release. Conclusion: The uniform design method combined with single factor experiment design to optimize the screening process of fluorouracil magnetic sub-microspheres is scientific and reasonable, which provides a theoretical basis for the preparation of fluorouracil magnetic sub-microspheres.