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采用免疫组化法检测 12 7例间叶组织肿瘤中PCNA、p53、pRb基因产物的表达与间叶组织肿瘤恶性程度的相关性。结果 :85例恶性间叶组织肿瘤中 ,PCNA、p53、pRb基因产物的阳性表达率分别为 84 7% ( 72 / 85) ,54 1% ( 4 6/ 85) ,58 8% ( 50 / 85) ;4 2例良性间叶组织肿瘤中 ,PC NA、p53、pRb基因产物的阳性表达率分别为 4 0 % ( 17/ 4 2 ) ,16 7% ( 7/ 4 2 ) ,2 1 4 % ( 9/ 4 2 )。两者差异显著 (P <0 0 0 1)。结果 :检测PCNA、p53、pRb基因产物表达有助于判断间叶组织肿瘤的良恶性和推测预后
The correlation between the expression of PCNA, p53, and pRb gene products and the degree of malignancy of mesenchymal tumors was examined by immunohistochemistry. Results: The positive expression rates of PCNA, p53, and pRb gene products were 84 7% (72/85), 54 1% (46/85), and 58 8% (50/85) in 85 malignant mesenchymal tumors. In 42 cases of benign mesenchymal tumors, the positive expression rates of PCNA, p53 and pRb gene products were 40% (17/42), 167% (7/42), and 21.4% respectively. (9/42). The difference between the two was significant (P < 0 0 0 1). Results : Detecting the expression of PCNA, p53, and pRb gene products was helpful to determine benign and malignant mesenchymal tumors and their prognosis.