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环氧司坦(epostane)是3β-羟甾脱氢酶抑制剂,能抑制卵巢和胎盘的3β-羟甾脱氢酶活性,阻断孕烯醇酮转变为孕酮,使血浆孕酮水平明显下降,对妊娠大鼠和猕猴均有明显的止孕作用。孕酮和利血平能对抗环氧司坦对大鼠和猕猴的止孕作用,hCG不能对抗环氧司坦对大鼠的止孕作用。初步临床研究结果证实环氧司坦有一定的终止早孕效果。与前列腺素合并应用则疗效可有进一步的提高。环氧司坦使用方便,毒副反应较小,是一种有前途的新型口服止孕剂。
Epostane is a 3β-hydroxysteroid dehydrogenase inhibitor that inhibits 3β-hydroxysteroid dehydrogenase activity in the ovary and placenta, blocks the conversion of pregnenolone to progesterone, and significantly increases plasma progesterone levels Decline, pregnant rats and macaques have obvious role in the pregnancy. Progesterone and reserpine antagonize the effects of cefoxitin on rats and macaques, and hCG can not counteract the effects of cefoxitin on rats. Preliminary clinical study confirmed that Epothilone had a certain effect of termination of early pregnancy. And prostaglandin combined application of the efficacy can be further improved. Epoxisan easy to use, less side effects, is a promising new type of oral agent.