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目的:研究小细胞肺癌患者血清中VEGF在γ-干扰素治疗前后的定量表达。方法:将58例小细胞肺癌的患者随机均分为两组,实验组应用γ-干扰素+化疗药物,对照组只应用化疗药物。用ELISA法检测两组化疗前后VEGF的含量。结果:对照组血清中VEGF的含量在化疗前后差异无统计学意义(P>0.05)。实验组血清中VEGF的含量在治疗前后差异有统计学意义(P<0.05)。结论:经γ-干扰素治疗后,患者血清中VEGF的含量明显下降。
Objective: To study the quantitative expression of VEGF in small cell lung cancer patients before and after γ-interferon treatment. Methods: Fifty-eight patients with small cell lung cancer were randomly divided into two groups. The experimental group was treated with IFN-γ and chemotherapy drugs while the control group only with chemotherapy drugs. The levels of VEGF in both groups before and after chemotherapy were detected by ELISA. Results: There was no significant difference in the levels of VEGF in serum before and after chemotherapy (P> 0.05). The content of VEGF in experimental group had significant difference before and after treatment (P <0.05). Conclusion: The serum levels of VEGF in patients after γ-interferon treatment significantly decreased.