天然免疫是人和动物免疫系统的重要组成部分,在抗感染过程中发挥关键作用,其中,血脑屏障是保护脑器官的天然卫士,能够阻止病原体和有害物质从血液进入脑组织和脑脊液,从而保护中枢神经系统稳定。血脑屏障通透性并非恒定不变,受到紧密连接和多种因子调控。本文综述了血脑屏障调节研究的进展。 Natural immunity is an important part of the immune system of humans and animals and plays a key role in the anti-infective process. The blood-brain barrier is a natural guardian of the brain that prevents pathogens and harmful substances from entering the bloodstream into the brain and cerebrospinal fluid Protect the central nervous system stability. Blood-brain barrier permeability is not constant and is regulated by tight junctions and multiple factors. This review summarizes the progress in the study of blood-brain barrier regulation.