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干扰素(IFN)具有抗增殖,免疫调节及抗病毒的特性.在体内外也能影响细胞的分化.一些临床试验已提示,IFN治疗基底细胞癌(BCC)有效.本文报道对一组172例经活检证实为结节溃疡型或浅表型BCC病人进行随机、双盲、安慰剂对照的多中心试验,以估价用重组的人白细胞IFNα-2b病灶内注射的疗效.其中130例每次用IFNα-2b1.5×10~6IU,42例用安慰剂,直接注射到BCC内,每周3次,共3周.IFN的累计量为13.5×10~6IU.安慰剂是IFN制剂的赋形剂,含有磷酸盐缓冲液、人白蛋白和甘氨酸.最后行组织学检查的IFN治疗组病人为120例.在20周时作活检确定疗效,IFN组的损害86%(103/120)治愈,而对照组则仅为
Interferon (IFN) has anti-proliferative, immunoregulatory, and antiviral properties. It also affects cell differentiation in vitro and in vivo. Several clinical trials have suggested that IFN therapy is effective for basal cell carcinoma (BCC). This article reports a pair of 172 cases. A biopsy-proven, randomized, double-blind, placebo-controlled, multicenter trial was performed for patients with nodular or superficial BCC to evaluate the efficacy of intralesional injection of recombinant human leukocyte IFNα-2b. Of these, 130 were used each time. IFNα-2b 1.5 × 10 ~ 6IU, 42 patients were injected directly into BCC with placebo, 3 times per week for 3 weeks. The cumulative amount of IFN was 13.5 × 10 ~ 6 IU. Placebo was the shaping of IFN preparation. The agent contained phosphate buffer, human albumin, and glycine. The final line of histological examination of the IFN-treated group was 120 patients. Biopsy was performed at 20 weeks to determine the efficacy, and 86% (103/120) of the IFN group lesions were cured. The control group only