目的探讨自由基清除剂治疗小儿肺炎的安全性及临床效果。方法选取2014年7月至2016年9月148例肺炎患儿,将其随机分成普通组和自由基组,每组74例。普通组给予常规的对症治疗措施,如吸氧、镇咳、抗生素、化痰、提高免疫力、抗病毒等,在此基础上自由基组静脉滴注丹参注射液进行治疗。观察记录两组患儿症状恢复时间、临床效果、不良反应的发生情况,治疗前、治疗后1、3 d血清中肝蛋白、一氧化氮、肿瘤坏死因子-α、丙二醛、C-反应蛋白表达水平,对其进行对照比较。结果自由基组治疗后临床总有效率94.59%(70/74)显著高于普通组的85.14%(63/74)(P<0.05);自由基组发热、咳嗽等肺炎症状复原时间为(5.62±2.04)d,普通组为(7.07±3.21)d,自由基组显著少于普通组(P<0.05);自由基组胃肠道反应、恶心头晕等不良反应发生率显著少于普通组(P<0.05);自由基组治疗后1、3 d血清中一氧化氮、肿瘤坏死因子-α、丙二醛、C-反应蛋白表达水平显著低于普通组(P<0.05);自由基组治疗后1、3 d血清中肝蛋白表达水平显著高于普通组(P<0.05)。结论应用自由基清除剂治疗小儿肺炎能安全快速有效地缓解病情,显著降低患儿血清中一氧化氮、肿瘤坏死因子-α、丙二醛、C-反应蛋白表达水平,提高肝蛋白表达能力,提高患儿生存质量,且见效快、不良反应少,能减少发生胃肠道反应、恶心头晕等不良反应概率,临床效果显著,值得临床应用。 Objective To investigate the safety and clinical efficacy of free radical scavenger in the treatment of children pneumonia. Methods 148 cases of children with pneumonia were selected from July 2014 to September 2016, and randomly divided into general group and free radical group, 74 cases in each group. Common group given conventional symptomatic treatment measures, such as oxygen, antitussive, antibiotics, phlegm, improve immunity, anti-virus, etc., on the basis of free radicals intravenous infusion of Salvia injection for treatment. The symptom recovery time, clinical effect and adverse reaction were observed and recorded in two groups. Serum levels of hepatic protein, nitric oxide, tumor necrosis factor-α, malondialdehyde, C-reaction Protein expression levels, compared to their comparison. Results After treatment, the total effective rate in the radical group was 94.59% (70/74), significantly higher than that in the normal group (85.14%, 63/74) (P <0.05). The recovery time of fever, cough and other pneumonia in the free radical group was 5.62 ± 2.04) d, and (7.07 ± 3.21) d in the normal group and significantly less in the free radical group than in the normal group (P <0.05). The incidences of gastrointestinal reactions, nausea and dizziness and other adverse reactions in the free radical group were significantly less than those in the normal group P <0.05). The levels of NO, TNF-α, MDA and C-reactive protein in the free radical group were significantly lower than those in the normal group on the 1st and 3rd post-treatment (P <0.05) The level of hepatic protein in serum at 1 and 3 days after treatment was significantly higher than that in normal group (P <0.05). Conclusion The application of free radical scavenger in the treatment of pneumonia in children can relieve the disease safely and quickly, reduce the expression of nitric oxide, tumor necrosis factor-α, malondialdehyde and C-reactive protein, and improve the expression of hepatic protein, Improve children’s quality of life, and quick, less adverse reactions, can reduce the occurrence of gastrointestinal reactions, nausea and dizziness and other adverse reactions probability, the clinical effect is significant, worthy of clinical application.