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目的 评价尿膀胱癌抗原 (UBC)和透明质酸 (HA)诊断膀胱癌的价值。 方法 研究对象 94例 ,其中膀胱癌患者 64例 ,泌尿系良性疾病患者 2 0例 ,健康对照组 10例。膀胱镜检查前取尿样分别进行UBC、HA和脱落细胞学检测 ,分析比较 3种方法的敏感性、特异性、阳性和阴性预测价值。 结果 以 12 μg/L为UBC诊断膀胱癌的临界值 ,以大于正常对照组尿液HA水平上限 14 4 .7ng/ml为HA阳性界值时 ,UBC和HA诊断膀胱癌的敏感性分别为 85.9%和 89.1% ,与脱落细胞学 (40 .6% )比较 ,差异有显著性意义 (P <0 .0 1) ,3种方法诊断膀胱癌的特异性分别为 85.0 %、80 .0 %和 95.0 % ,阳性预测值分别为 94.8%、93 .4%和 96.3 % ,阴性预测值分别为 65.4%、72 .7%和 3 3 .3 %。 结论 尿UBC和HA检测技术简单 ,有较高的敏感性和特异性 ,可作为早期诊断膀胱癌的较好的肿瘤标记物。
Objective To evaluate the diagnostic value of urinary bladder cancer antigen (UBC) and hyaluronic acid (HA) in the diagnosis of bladder cancer. Methods 94 cases were studied, including 64 cases of bladder cancer, 20 cases of benign urinary diseases, and 10 cases of healthy control group. Urine samples taken before cystoscopy were detected by UBC, HA and exfoliative cytology. The sensitivity, specificity, positive and negative predictive value of the three methods were analyzed. Results The diagnostic value of UBC and HA in diagnosis of bladder cancer was 12.9% when the critical value of bladder cancer was 12 μg / L for UBC, and 14.47 ng / ml for HA as the positive value of HA in urine of normal control group % And 89.1%, respectively, compared with exfoliated cytology (40.6%), the difference was significant (P <0.01). The specificity of the three methods in diagnosing bladder cancer were 85.0%, 80.0% and The positive predictive value was 94.8%, 93.4% and 96.3% respectively, and the negative predictive value was 65.4%, 72.7% and 33.3% respectively. Conclusion The urinary UBC and HA detection techniques are simple, sensitive and specific, which can be used as a good tumor marker for early diagnosis of bladder cancer.