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目的研究乳腺癌危险因素,探讨不同因素间的交互作用对乳腺癌发生的影响。方法运用病例-对照研究,以Logistic回归分析危险因素及可能存在的交互作用。结果初潮早、首或末次怀孕年龄晚、痛经是乳腺癌的危险因素,调整OR(95%CI)分别为:1.79(1.26~2.55),1.56(1.10~2.20),1.49(1.04~2.15),1.88(1.22~2.90)。哺乳和生育可能降低乳腺癌发生风险。初潮早和首(末)次怀孕年龄晚、不饮茶和初潮早、首(末)次怀孕年龄晚、乳腺癌家族史间均具有联合作用(Ptrend<0.01)。初潮早和不饮茶以及首次怀孕晚和不饮茶间具有显著的相乘交互作用(Pint值分别为0.029和0.000)结论初潮早和首(末)次怀孕年龄晚是乳腺癌的危险因素,饮茶可显著降低发病风险,无饮茶史合并初潮早和首(末)次怀孕年龄晚显著增加乳腺癌发病风险。
Objective To study the risk factors of breast cancer and to explore the impact of different factors on the occurrence of breast cancer. Methods Using case-control study, Logistic regression analysis of risk factors and possible interactions. Results Early menarche and early or late pregnancy were the risk factors of breast cancer. The adjusted OR (95% CI) were 1.79 (1.26-2.55), 1.56 (1.10-2.20), 1.49 (1.04-2.15) 1.88 (1.22 ~ 2.90). Breastfeeding and childbirth may reduce the risk of breast cancer. Early menarche and first (last) second trimester of pregnancy were late, no tea and early menarche, first (last) second trimester of pregnancy, breast cancer family history have a combined effect (Ptrend <0.01). Significant multiplying interactions between early menarche and no-drink-tea and first-late-night and no-drink-tea (P = 0.029 and 0.000, respectively) concluded that early menarche and the first (last) second trimester of pregnancy were late risk factors for breast cancer, Drinking tea can significantly reduce the risk of onset, no history of drinking tea combined with early menarche and first (last) gestational age significantly increased the risk of breast cancer.