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目的探讨胺碘酮治疗慢性心力衰竭合并室性早搏的有效性和安全性。方法对50例慢性心力衰竭并发有症状的室性早搏患者,在常规抗心力衰竭治疗基础上,口服胺碘酮,应用24 h动态心电图、超声心动图评价治疗室性早搏效果、心功能变化、心率、QT间期变化和不良反应。结果治疗3个月后50例患者中,室性心律失常治疗有效率为96.0%,有效48例。治疗前后左室射血分数(LVEF)差异有统计学意义(P<0.001),未出现严重不良反应。结论胺碘酮治疗慢性心力衰竭合并室性早搏是有效和安全的。
Objective To investigate the efficacy and safety of amiodarone in the treatment of chronic heart failure complicated with ventricular premature beats. Methods Fifty patients with symptomatic ventricular premature beats complicated by chronic heart failure were treated with routine anti-heart failure. Amiodarone was given orally. 24-hour ambulatory electrocardiogram and echocardiography were used to evaluate the effects of ventricular premature beats, changes of cardiac function, Heart rate, QT interval changes and adverse reactions. Results 50 patients after 3 months of treatment, ventricular arrhythmia treatment efficiency was 96.0%, effective 48 cases. Before and after treatment, left ventricular ejection fraction (LVEF) difference was statistically significant (P <0.001), no serious adverse reactions. Conclusions Amiodarone is effective and safe in the treatment of chronic heart failure complicated with ventricular premature beats.