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目的研究急性ST段抬高型心肌梗死(STEMI)患者入院白细胞(WBC)计数与梗死面积的相关性及其对预后的影响。方法分析1078例急性STEMI患者,于胸痛发作<12h采血并采集心血管危险因素,分析患者入院WBC计数与临床指标的相关性。结果肌酸激酶(CK)峰值和肌酸激酶同工酶(CK-MB)峰值均与WBC计数呈显著正相关(r=0.321,P<0.01;r=0.276,P<0.01);CK和CK-MB的入院基础值也与WBC计数呈正相关性(r=0.132,P<0.01;r=0.077,P<0.05)。另外,入院WBC计数与患者的年龄呈显著负相关(r=-0.178,P<0.01)。结论急性STEMI患者入院WBC计数升高可能主要与梗死面积有关;未来应用WBC计数作为危险分层时,需考虑年龄因素的影响。
Objective To investigate the correlation between admission white blood cell count (WBC) and infarct size in patients with acute ST-elevation myocardial infarction (STEMI) and its effect on prognosis. Methods A total of 1078 patients with acute STEMI were enrolled in this study. Cardiovascular risk factors were collected at <12 hours after onset of chest pain. The correlation between admission WBC count and clinical parameters was analyzed. Results The peak values of creatine kinase (CK) and CK-MB were positively correlated with WBC counts (r = 0.321, P <0.01; r = 0.276, P <0.01) The baseline values of -MB were also positively correlated with WBC counts (r = 0.132, P <0.01; r = 0.077, P <0.05). In addition, there was a significant negative correlation between admission WBC count and patient’s age (r = -0.178, P <0.01). Conclusion The increase of admission WBC count in patients with acute STEMI may be mainly related to the infarct size. When using WBC count as risk stratification in future, the influence of age factor should be considered.