磷酸伯氨喹啉(简称伯喹)是间日疟治疗中迄今为止,视为毒性最小、效果最好的抗复发药。即使这样,伯喹仍有疗程过长,毒性较大等缺点,临床应用受到一定的限制。为此,多少年来国内外学者致力于伯喹结构的改造和构效关系的探索,借以寻找高效低毒的新抗复发药,已成为当前抗疟药研究中 Primary quinoline phosphate (referred to as primary quinoa) is so far in the treatment of Plasmodium vivax, regarded as the least toxic, the best antiretroviral drugs. Even so, Boquine is still long course of treatment, toxicity and other shortcomings, clinical application subject to certain restrictions. For this reason, for many years, domestic and foreign scholars have devoted themselves to the transformation of the structure of becoquine and the exploration of the structure-activity relationship, so as to find a new anti-recurrent drug with high efficiency and low toxicity, which has become the current antimalarial drug research