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目的:探讨同种异体肾移植的HLA配型效果。方法:比较同种异体肾移植中采用传统HLA配型方法与CREG配型方法的移植状况;对比HLA配型组和未配型组1年移植效果的不同。结果:HLA抗原出现频率较高的有HLA-A2、A11、A24、B60(40)、B13、DR15、DR51、DR52、DR53、DR 4。根据HLA 6位点相配原则,0~6个位点错配(mismatch,MM)所占比例分别为0.78%、1.56%、5.06%、10.12%、27.63%、29.96%和24.9%;而采用交叉组间配型原则(CREGs),0~6位点错配率分别为3.89%、6.23%、17.51%、33.85%、19.84%、13.23%、5.45%。结论:具有某些HLA位点的受者相对来说有更多的获得良好HLA配型的机会;CREGs配型原则明显提高了供、受者间的相配率,但移植效果仍有争议。
Objective: To investigate the HLA matching effect of allogeneic kidney transplantation. Methods: The transplantation status of allogeneic kidney transplantation using traditional HLA matching method and CREG matching method was compared. The difference of 1 year transplantation effect between HLA matching group and non-matching group was compared. Results: HLA-A2, A11, A24, B60 (40), B13, DR15, DR51, DR52, DR53 and DR 4 were found in high frequency of HLA antigens. According to the matching principle of HLA 6 loci, the proportion of mismatch (MM) between 0 and 6 loci was 0.78%, 1.56%, 5.06%, 10.12%, 27.63%, 29.96% and 24.9% The mismatch rates of CREGs and loci from 0 to 6 were 3.89%, 6.23%, 17.51%, 33.85%, 19.84%, 13.23% and 5.45%, respectively. CONCLUSIONS: Recipients with certain HLA loci have more chances of obtaining good HLA matches relatively. CREGs matching principle significantly improves the matching rate between donors and recipients, but the effect of transplantation is still controversial.