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DNA甲基化是一种表观遗传学修饰方式,与多种疾病存在重要关联,日益成为研究的热点。DNA甲基化修饰虽然不会引起DNA序列的改变,却可干扰基因的表达。原发性高血压是一种严重影响人类健康的慢性疾病,已成为全球共同关注的公共卫生问题。原发性高血压与DNA甲基化存在着重要关联,因此,了解原发性高血压主要危险因素与DNA甲基化的关系,可以更好地解释原发性高血压和DNA甲基化之间的因果关系。现就原发性高血压主要危险因素与DNA甲基化关系的研究进展作一综述。
DNA methylation is an epigenetic modification, which has an important relationship with many diseases and is increasingly becoming a hot spot for research. Although DNA methylation does not cause DNA sequence changes, it can interfere with the gene expression. Essential hypertension is a chronic disease that seriously affects human health and has become a public health issue of common concern worldwide. Essential hypertension and DNA methylation is an important link, therefore, to understand the relationship between the main risk factors of essential hypertension and DNA methylation, can better explain the primary hypertension and DNA methylation The causal relationship between. The research progress on the relationship between major risk factors of hypertension and DNA methylation is reviewed.