T细胞大颗粒淋巴细胞性白血病是一种罕见的淋巴组织增生性疾病,往往与自身免疫性疾病和免疫介导的血细胞减少相关。Hanna LM等人对此进行研究,对76例克隆性的T细胞受体重排和大颗粒淋巴细胞增多的患者进行了目标序列捕获测序。结果:有31例发生STAT3突变,所有的突变都分部在外显子21、编码Src同源2结构域,即一个介导二聚化和激活STAT T-cell large granulocytic leukemia is a rare form of lymphoproliferative disease that is often associated with autoimmune diseases and immune-mediated cytopenias. Hanna LM et al. Conducted a targeted sequencing of 76 patients with clonal T cell receptor rearrangements and large granulocytosis. RESULTS: There were 31 cases of STAT3 mutations, all with mutations in exon 21 encoding the Src homology 2 domain, a mediator of dimerization and activation of STAT