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目的分析大剂量激素冲击疗法联合高压氧治疗急性一氧化碳中毒迟发性脑病临床效果。方法 84例急性一氧化碳中毒迟发性脑病(DEACMP)患者随机分为观察组与对照组,每组42例,对照组使用常规高压氧,同时给予改善微循环、脑保护剂、抗氧化自由基等药物治疗;观察组则在对照组治疗基础上,临床一出现迟发性脑病症状即给予甲基强的松冲击治疗。结果观察组痊愈69.0%,有效23.8%,无效7.2%,观察组无死亡病例,总有效率为92.8%,患者的平均住院时间为35 d。对照组痊愈42.9%,有效26.2%,无效28.6%,1例患者死亡,对照组的总有效率为69.1%,患者的平均住院时间为43 d。观察组通过大剂量激素冲击疗法联合高压氧治疗急性一氧化碳中毒迟发性脑病的有效率要超过对照组,差异有统计学意义(P<0.05)。结论使用大剂量激素冲击治疗能有效遏制一氧化碳中毒迟发性脑病的进展加重,可缩短疗程、减少住院时间、提高生存率,值得在临床推广。
Objective To analyze the clinical effect of high-dose hormone shock therapy combined with hyperbaric oxygen on delayed encephalopathy after acute carbon monoxide poisoning. Methods Eighty-four patients with DEACMP were randomly divided into observation group and control group, with 42 cases in each group. The control group was given conventional hyperbaric oxygen while improving the microcirculation, brain protectant and antioxidant free radical Drug treatment; the observation group was in the control group based on the treatment of clinical symptoms of delayed encephalopathy that given methylprednisone impact treatment. Results The observation group recovered 69.0%, effective 23.8%, ineffective 7.2%, the observation group no deaths, the total effective rate was 92.8%, the average length of stay of patients was 35 days. The control group was cured 42.9%, effective 26.2%, ineffective 28.6%, 1 patient died, the control group, the total effective rate was 69.1%, the average hospital stay was 43 days. Observation group through high-dose hormone therapy combined with hyperbaric oxygen treatment of acute carbon monoxide poisoning delayed encephalopathy more effective than the control group, the difference was statistically significant (P <0.05). Conclusion The use of high-dose hormonal shock therapy can effectively curb the progress of delayed encephalopathy caused by carbon monoxide poisoning, which can shorten the course of treatment, reduce the hospitalization time and improve the survival rate, which is worthy of clinical promotion.