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目的 研究p16在宫颈癌的表达及与临床分期的相关性。方法 用免疫组化方法检测了10例正常宫颈组织、13例慢性宫颈炎和35例宫颈癌组织中p16的表达。结果 p16在宫颈癌的阳性率为48.6％,其表达与宫颈癌的临床分期、淋巴结转移显著相关(P<0.05)。结论 P16与宫颈癌的病程进展显著相关,可作为判定预后的一项重要参考指标。
Objective To study the expression of p16 in cervical cancer and its relationship with clinical stage. Methods Immunohistochemistry was used to detect the expression of p16 in 10 cases of normal cervical tissue, 13 cases of chronic cervicitis and 35 cases of cervical cancer. Results The positive rate of p16 in cervical cancer was 48.6%. The expression of p16 was significantly correlated with the clinical stage and lymph node metastasis (P <0.05). Conclusions P16 is significantly associated with the progression of cervical cancer and can be used as an important reference index for prognosis.