目前抑癌基因成为癌变机制研究的热点，其中ｐ５３尤其令人瞩目。世界上每天被确诊为癌症的６．５万人中约５０％是由于ｐ５３基因突变引发的，并且发现有５１种以上肿瘤与ｐ５３突变有关，其中包括卵巢癌。在女性生殖器肿瘤中，卵巢癌最具致死性，确诊后五年生存率不足２５％。本文综述卵巢癌手术标本及细胞系中，ｐ５３基因丢失、突变及ｐ５３蛋白过度表达情况，探讨其相关的病因学因素。 At present, tumor suppressor genes become the focus of research on the mechanism of carcinogenesis, of which p53 is particularly notable. Approximately 50% of the 65,000 people diagnosed with cancer worldwide each day are caused by mutations in the p53 gene and more than 51 tumors have been found to be associated with p53 mutations, including ovarian cancer. In female genital tumors, the most lethal ovarian cancer, five-year survival after diagnosis less than 25%. This review summarizes the loss and mutation of p53 gene and p53 protein overexpression in ovarian cancer specimens and cell lines, and discusses the etiological factors involved.