Toll样受体家族是一种识别微生物体上保守结构——病原体相关的分子结构的模式识别受体。它可以表达于肠道粘膜的多种细胞中,介导微生物与细胞之间的相互作用,在粘膜免疫中发挥重要作用。近年来的研究显示,炎症性肠病与肠道免疫异常和粘膜稳态破坏相关,而Toll样受体在其中具有重要的作用。 The Toll-like receptor family is a pattern recognition receptor that recognizes the conserved structure on a microorganism, the pathogen-associated molecular structure. It can express a variety of cells in the intestinal mucosa, mediate the interaction between microorganisms and cells, play an important role in mucosal immunity. Recent studies have shown that inflammatory bowel disease is associated with intestinal immune dysfunction and mucosal homeostasis, and Toll-like receptors play an important role.