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碱性成纤维细胞生长因子（ bFGF）是一种多功能肽类物质，通过旁分泌或自分泌的方式促进细胞分化、增殖以及血管生成。 bFGF在胎盘中主要参与血管和滋养层细胞的生成、增殖和分化，促进子宫螺旋动脉形成以及滋养层细胞侵入子宫内膜，维持胎盘血管的正常功能。在产科疾病中发现，bFGF在妊娠期高血压疾病、妊娠糖尿病以及胎儿生长受限等疾病的初期表达上调，而当疾病发展严重时，bFGF的表达下降。“,”Basic fibroblast growth factor(bFGF) is a multifunctional peptide,which promotes cell differ-entiation,proliferation,and angiogenesis by paracrine secretion and autocrine.In placenta,bFGF is mainly involved in vascular and trophoblast cell formation,proliferation and differentiation,promotes uterine spiral arteries and trophoblast cells to invade the endometrium ,and maintains the normal function of placental ves-sels.In obstetric diseases,bFGF expression is upregulated in the early stages of gestational hypertension,ges-tational diabetes and fetal growth restriction and other diseases,but when the disease is serious,the expression of bFGF is decreased.