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目的探讨冻融囊胚移植子宫内膜准备方法。方法回顾性分析该中心2012年5月-2014年5月633个冻融囊胚移植周期,其中A组为自然周期412例,B组为促排卵周期85例,C组为激素替代周期136例,将3组患者资料进行比较。结果C组子宫内膜厚度显著低于A组和B组,差异有统计学意义(P<0.05)。3组的临床妊娠率分别为52.2%、42.4%、55.9%,种植率分别为41.2%、33.1%、45.1%,A组与C组相比,临床妊娠率和种植率差异均无统计学意义(均P>0.05);B组与C组相比,临床妊娠率和种植率显著降低,差异均有统计学意义(均P≤0.05)。结论自然周期是简单、经济、有效的冻融囊胚移植子宫内膜准备方法,适用于有规律排卵的患者。激素替代周期安全、灵活、有效,是排卵障碍患者的最佳选择。临床上应因人而异,选择适宜的子宫内膜准备方案行冻融囊胚移植。
Objective To investigate the method of endometrial preparation for frozen-thawed blastocyst transplantation. Methods A retrospective analysis of the center from May 2012 to May 2014 633 cycles of frozen and thawed blastocysts, including a group of 412 cases of natural cycles, B group ovulation cycle 85 cases, C group 136 cases of hormone replacement cycle , The three groups of patients were compared. Results The thickness of endometrium in group C was significantly lower than that in group A and group B, the difference was statistically significant (P <0.05). The clinical pregnancy rates of the three groups were 52.2%, 42.4% and 55.9% respectively, the implantation rates were 41.2%, 33.1% and 45.1% respectively. There was no significant difference in clinical pregnancy rate and implantation rate between group A and group C (All P> 0.05). Compared with group C, clinical pregnancy rate and implantation rate in group B were significantly lower (all P≤0.05). Conclusion The natural cycle is a simple, economical and effective method of endometrial preparation for frozen-thawed blastocyst transplantation, which is suitable for patients with regular ovulation. Hormone replacement cycle safe, flexible and effective, is the best choice for patients with ovulation disorders. Clinical should vary from person to person, select the appropriate endometrial preparation program frozen and blastocyst transplantation.