特异性多能转录因子及其作用的研究进展

来源 :国际口腔医学杂志 | 被引量 : 0次 | 上传用户：aaa939639017

【摘要】

：

将自胚胎干细胞中筛选出的oct-4、sox一2、c-mye、klf-4四种基因组合转入体细胞,可获得与胚胎干细胞类似的诱导性多能干细胞.牙髓干细胞取材简单,尝试利用特异性多能转录因子

【作者】

：

张芳周晓燕

【机构】

：

中山大学光华口腔医学院·附属口腔医院·口腔医学研究所

【出处】

：

国际口腔医学杂志

【发表日期】

：

2004年期

【关键词】

：

去分化牙髓干细胞多能干细胞多能转录因子

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将自胚胎干细胞中筛选出的oct-4、sox一2、c-mye、klf-4四种基因组合转入体细胞,可获得与胚胎干细胞类似的诱导性多能干细胞.牙髓干细胞取材简单,尝试利用特异性多能转录因子将其重编程为与胚胎干细胞类似的诱导性多能干细胞,可为牙组织工程提供优质的种子细胞.本文就特异性多能转录因子的结构和功能、在体细胞去分化中的作用、在肿瘤发生中的作用、在牙髓细胞中的表达及其意义等作一综述.

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特异性多能转录因子及其作用的研究进展

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