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[目的]观察五藤散外敷联合西药治疗急性期寒湿阻络型类风湿关节炎的临床疗效和安全性。[方法]采用随机、对照方法。将100例急性期寒湿阻络型类风湿关节炎患者,随机分为治疗组和对照组各50例,治疗组采用五藤散(主要成分:雷公藤、青风藤、鸡血藤等)外敷疼痛关节,1次/d;对照组口服美洛昔康7.5mg,2次/d;两组均常规服用甲氨蝶呤15mg、叶酸片10mg,1次/周。治疗20d对两组患者晨僵时间、关节疼痛程度、关节肿胀程度、关节活动程度及血沉、C反应蛋白、类风湿因子等实验室指标进行比较,观察两组患者在治疗过程中的不良反应。[结果]两组患者在治疗前后临床疗效、症状体征积分及实验室指标均有不同程度的改善,但治疗组与对照组比较无显著性差异(P>0.05)。两组患者治疗前后关节疼痛度、晨僵时间、肿胀度、活动度、ESR、CRP、RF等指标均较治疗前有不同程度的改善(P<0.01)。[结论]五藤散治疗寒湿阻络型类风湿关节炎急性期关节症状与非甾体类消炎止痛药美洛昔康疗效相当,且无明显副作用,值得临床推广。
[Objective] To observe the clinical efficacy and safety of wu teng powder combined with western medicine in treating acute rheumatic arthritis with rheumatoid arthritis. [Methods] A randomized, controlled method was used. 100 patients with acute rheumatoid arthritis of rheumatoid arthritis group were randomly divided into treatment group and control group of 50 cases, the treatment group using Wu Teng San (main components: Tripterygium, Qingfeng vine, Millettia, etc.) external application Painful joints, 1 time / d; control group, oral meloxicam 7.5mg, 2 times / d; methotrexate 15mg, folic acid tablets 10mg, 1 times / week. After 20 days of treatment, morning sickness, joint pain, degree of joint swelling, degree of joint activity and ESR, C-reactive protein and rheumatoid factor were compared between the two groups. The adverse reactions in the two groups were observed. [Results] Before and after treatment, the clinical curative effect, symptom and symptom score and laboratory indexes all improved to some extent, but there was no significant difference between the treatment group and the control group (P> 0.05). Before and after treatment, joint pain, morning stiffness, swelling, activity, ESR, CRP and RF in both groups were all improved to some extent before treatment (P <0.01). [Conclusion] Wutengsan is effective in treating acute rheumatoid arthritis with rheumatoid arthritis and non-steroidal anti-inflammatory analgesic meloxicam, and has no obvious side effects and is worthy of clinical promotion.