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目的 :探讨抗心磷脂抗体 (ACA)及抗DNA抗体检测在反复自然流产 (RSA)诊断中的意义。 方法 :应用ELISA法检测 5 6例RSA病人血清ACA与抗DNA ,与对照组 38例比较。 结果 :RSA组ACA、抗ss DNA阳性率分别为 32 .1% (18/ 5 6 )、2 1.4% (12 / 5 6 )较对照组 5 .2 % (2 / 38)、5 .2 % (2 / 38)明显增高 (P <0 .0 1)。三种类别ACA以IgG、IgM型检出率高 ,抗ds DNA阳性率为 3.5 % (2 / 5 6 )。 结论 :ACA及抗ss DNA与RSA密切相关 ,抗ds DNA对诊断RSA无明显意义。
Objective: To investigate the significance of anticardiolipin antibody (ACA) and anti-DNA antibody in the diagnosis of recurrent spontaneous abortion (RSA). Methods: Serum ACA and anti-DNA of 56 RSA patients were detected by ELISA, compared with 38 cases of control group. Results: The positive rates of ACA and anti-ss DNA in RSA group were 32.1% (18/56), 21.4% (12/56) in control group, 5.2% (2/38) and 5.2% (2/38) was significantly higher (P <0.01). The three categories of ACA with IgG, IgM detection rate was high, anti-dsDNA positive rate was 3.5% (2/56). Conclusion: ACA and anti-ss DNA are closely related to RSA. Anti-ds DNA has no significant effect on the diagnosis of RSA.