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冠状动脉粥样硬化性心脏病是严重危害人类健康的常见疾病,是一种多因素、多基因疾病。遗传流行病学研究显示遗传因素在冠状动脉粥样硬化性心脏病的发生、发展中有重要意义。近年来随着分子生物学技术的迅速发展,从基因方面阐明冠状动脉粥样硬化性心脏病的发生将为冠状动脉粥样硬化性心脏病的诊治开辟一个新领域。在此对其中的一种候选基因即间隙性连接蛋白37C1019T基因多态性与冠状动脉粥样硬化性心脏病的相关性研究进行综述。
Coronary atherosclerotic heart disease is a common disease that seriously endangers human health and is a multifactorial, polygenic disease. Genetic epidemiological studies have shown that genetic factors in coronary atherosclerotic heart disease, the development of great significance. In recent years, with the rapid development of molecular biology technology, elucidating the occurrence of coronary atherosclerotic heart disease from the gene will open up a new field for the diagnosis and treatment of coronary atherosclerotic heart disease. Here one of the candidate genes, namely the gap junction protein 37C1019T gene polymorphism and coronary heart disease research are reviewed.